EVALUASI PENGGUNAAN ANTIBIOTIK PROFILAKSIS PADA PASIEN BEDAH DI RUMAH SAKIT BALA KESELAMATAN BOKOR DENGAN METODE DEFINE DAILY DOSE DAN GYSSENS
DOI:
https://doi.org/10.33479/sb.v4i1.258Abstract
Infectious diseases remain a significant public health concern, especially in developing countries. Infection involves the transmission and multiplication of infectious agents within the host's body. An infection is a condition caused by pathogenic microorganisms, with or without accompanying clinical symptoms (Ministry of Health of the Republic of Indonesia, 2017). The aim of this study is to provide an overview of surgical patients and the pattern of antibiotic use based on the DDD and Gyssen methods at Bala Keselamatan Bokor Hospital. This observational study was conducted retrospectively by reviewing patients' medical records at the hospital from January 1 to March 31, 2023. The data were then analyzed using the Gyssens and ATC/DDD methods. The results of the study showed that surgical patients have two main characteristics based on age and gender. The highest age range was 56 to 65 years, accounting for (25%) of the cases, with the majority being male, constituting (28%) of the cases. The second-highest age range was 46 to 56 years, making up (23%) of the cases, with females comprising (29%) of the cases. Regarding the evaluation of the quantity of antibiotic use using the ATC/DDD method, the highest DDD value was observed for ceftriaxone with a percentage of (7.6%).
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References
Ahmed, N. J., Haseeb, A., Alamer, A., Almalki, Z. S.,
Alahmari, A. K., & Khan, A. H. (2022). MetaAnalysis of
Clinical Trials Comparing Cefazolin to
Cefuroxime, Ceftriaxone, and Cefamandole for Surgical
Site Infection Prevention. Antibiotics,
(11). https://doi.org/10.3390/antibiotics11111543
Anggraini, W., Puspitasari, M. R., Ramadhani, R., Atmaja,
D., & Sugihantoro, H. (2020). Pengaruh Pemberian
Edukasi Terhadap Tingkat Pengetahuan Pasien Rawat
Jalan Tentang Penggunaan Antibiotik Di
RSUDKanjuruhan Kabupaten
Malang. Pharmaceutical journal of indonesia, 6(1),
–62. http://.pji.ub.ac.id
Bratzler, D. W., Dellinger, E. P., Olsen, K. M., Perl, T. M.,
Auwaerter, P. G., Bolon, M. K., Fish, D. N., Napolitano, L.
M., Sawyer, R. G., Slain, D., Steinberg, J. P., & Weinstein,
R. A. (2013). Clinical practice guidelines for antimicrobial
prophylaxis in surgery. American Journal of Health-
System
Pharmacy, 70(3), 195–283.
https://doi.org/10.2146/ajhp120568
Carolina, M., & Widayati, A. (2014a). Evaluasi
Penggunaan Antibiotika dengan Metode DDD (defined
daily dose) pada Pasien Anak Rawat Inap di Sebuah
Rumah Sakit Pemerintah di Yogyakarta Periode Januari-
Juni 2013. Media Farmasi, 11(1),
–89.
Erdani, F., Novika, R., Ramadhana, I. F., Bedah, K.,
Zainoel, R. D., Fakultas, A. /, Universitas, K., Kuala, S.,
Aceh-Indonesia, B., Farmasi, B., & Banda Aceh-
Indonesia, A. (2020). Evaluasi Penggunaan Antibiotik
Profilaksis terhadap Kejadian Infeksi Luka Operasi pada
Operasi Bersih dan Bersih Terkontaminasi di RSUD dr.
Zainoel Abidin. Journal of Medical Science Jurnal Ilmu
Medis Rumah Sakit Umum Dr. Zainoel Abidin, Banda
Aceh, 1(2), 67–73.
Flor, M., Tenhagen, B. A., & Käsbohrer, A. (2022).
Contrasting Treatment- and Farm-Level Metrics of
Antimicrobial Use Based on Used Daily Dose vs. Defined
Daily Dose for the German Antibiotics Minimization
Concept. Frontiers in Veterinary Science, 9.
https://doi.org/10.3389/fvets.2022.913197
Foti, C., Piperno, A., Scala, A., & Giuffrè, O. (2021).
Oxazolidinone antibiotics: Chemical, biological and
analytical aspects. In Molecules (Vol. 26, Issue 14). MDPI
AG. https://doi.org/10.3390/molecules26144280
Haryanti, L., Pudjiadi, A. H., Irfan, E. K. B., Thayeb, A.,
Amir, I., & Hegar, B. (2013). Prevalens dan Faktor Risiko
Infeksi Luka Operasi Pasca-bedah. Sari Pediatri, 15(4),
–213.
Hasneli Yesi, (2014). Faktor-faktor yang mempengaruhi
tingkat kecemasan pasien fraktur tulang panjang Pra
operasi yang di rawat di RSUD Arifin Achmad Pekanbaru.
Heningtyas, S. A. P., & Hendriani, R. (2017). Evaluasi
Penggunaan Antibiotik pada Pasien Rawat inap di rumah
sakit “x” provinsi jawa baratsecara kuantitatif padabulan
november-desember 2017.
Farmaka, 16(2), 97–105.
Herdianti, C. D., Primariawan, R. Y., Rusiani, D. R., &
Soeliono, I. (2020). Evaluasi Penggunaan Antibiotik
menggunakan Indeks ATC/DDD dan DU90% pada Pasien
Operasi TAH BSO dengan Infeksi Daerah Operasi: Studi
Retrospektif di RSUD Dr. Soetomo. Jurnal Sains Farmasi
& Klinis, 7(3), 188.
https://doi.org/10.25077/jsfk.7.3.188-193.2020
Ilham Novalisa Aji Wibowo, M., Dwi Utamiasih, T., &
Ratna Juwita, D. (2019). Evaluasi Penggunaan Antibiotik
Profilaksis pada Operasi Sesar di Rumah Sakit Swasta
Purwokerto Evaluation of Prophylactic Antibiotic
Use for Cesarean Section In a Purwokerto Private
Hospital. In Pharmaceutical Journal of Indonesia (Vol. 16,
Issue 02).
Kalawar, R. P. S., Shrestha, B., Khanal, G., Chaudhary, P.,
Rijal, R., Maharjan, R., dan Paneru, S. (2018).
Randomized controlled trial comparing cefazolin with
ceftriaxone in perioperative prophylaxis in orthopaedic
surgeries. Journal of BP Koirala Institute of Health
Sciences, 1(1), 36–43.
https://doi.org/10.3126/jbpkihs.v1i1.19752.
Kemenkes. (2015). Peraturan Menteri KesehatanRepublik
Indonesia Nomor 8 Tahun 2015tentang Program
Pengendalian ResistensiAntimikroba di Rumah Sakit.
Jakarta.Kementrian Kesehatan Republik Indonesia.
(Vol. 1).
Meriyani, H., Sanjaya, D. A., Sutariani, N. W., Juanita,
RR. A., & Siada, N. B. (2021). Antibiotic Use and
Resistance at Intensive Care Unit of a Regional Public
Hospital in Bali: A 3-Year Ecological Study. Indonesian
Journal of Clinical Pharmacy, 10(3),
–189. https://doi.org/10.15416/ijcp.2021.10.3.180
Moser, C., Lerche, C. J., Thomsen, K., Hartvig, T.,
Schierbeck, J., Jensen, P. Ø., Ciofu, O., & Høiby, N.
(2019). Antibiotic therapy as personalized medicine –
general considerations and complicating factors. In APMIS
(Vol. 127, Issue 5, pp. 361–371). Blackwell Munksgaard.
https://doi.org/10.1111/apm.12951
Muller, A., Monnet, D. L., Talon, D., Hénon, T., &
Bertrand, X. (2006). Discrepancies between prescribed
daily doses and WHO defined daily doses of antibacterials
at a university hospital. British Journal of Clinical
Pharmacology, 61(5), 585–591.
https://doi.org/10.1111/j.1365-2125.2006.02605.x
Najjar, P. A., dan Smink, D. S. (2015). Prophylactic
Antibiotics and Prevention of Surgical Site Infections.
Surgical Clinics of North America, 95(2), 269–283.
https://doi.org/10.1016/j.suc.2014.11.006.
Nisak, N. A., Yulia, R., Hartono, R., & Herawati, F.
(2022a). Evaluasi Penggunaan Antibiotik pada Pasien
Bedah Bersih Terkontaminasi di Rumah Sakit
Bhayangkara Surabaya. Jurnal Pharmascience, 9(1), 1–10.
https://ppjp.ulm.ac.id/journal/index.php/pharmascie nce
Normaliska, R., Bachrum Sudarwanto, M., Latif, H., Besar
Karantina Pertanian Tanjung Priok, B., Karantina
Pertanian, B., Studi Kesehatan
Masyarakat Veteriner Sekolah Pascasarjana IPB, P., Ilmu
Penyakit Hewan dan Kesehatan Masyarakat Veteriner, D.,
& Kedokteran Hewan, F. (2019). Pola Resistensi
Antibiotik pada Escherichia coli Penghasil ESBL dari
Sampel Lingkungan di RPH-R
Kota Bogor (Antibiotic Resistance of ESBLProducing
Escherichia coli from Environmental Samples in Bogor
Slaughterhouse). ACTA veterinaria indonesiana, 7(2), 42–
http://www.journal.ipb.ac.id/indeks.php/actavetindo nes
Panduan, B., Hari, P., Sedunia, K., Antibiotik, G., Tepat,
S., Mencegah, U., & Kuman, K. (2011). Kementerian
kesehatan republik indonesia.
Phoolcharoen, N., Nilgate, S., Rattanapuntamanee, O.,
Limpongsanurak, S., dan Chaithongwongwatthana, S.
(2012). A randomized controlled trial comparing
ceftriaxone with cefazolin for antibiotic prophylaxis in
abdominal hysterectomy. International Journal of
Gynecology & Obstetrics, 119(1), 11–13.
https://doi.org/10.1016/j.ijgo.2012.04.023.
Pratiwi, A. I., Wiyono, W. I., & Jayanto, I. (2020).
Pengetahuan Dan Penggunaan Antibiotik Secara
Swamedikasi Pada Masyarakat Kota. Jurnal
Biomedik:JBM, 12(3), 176.
https://doi.org/10.35790/jbm.12.3.2020.31492
Rostinawati, T. (2021). Pola Resistensi Antibiotik Bakteri
Penyebab Infeksi Saluran Kemih di Puskesmas Ibrahim
Adjie Kota Bandung. Jurnal Sains Farmasi &Klinis, 8(1),
https://doi.org/10.25077/jsfk.8.1.27-34.2021
Sagita, D., pratama, S., Studi Farmasi, P., Harapan Ibu
Jambi, S., & Adiwangsa Jambi, U. (2020). Uji Resistensi
Antibiotik Terhadap Kultur Bakteri Staphylococcus aureus
pada Ruang Intensive Care Unit (ICU) Rumah Sakit
YKota Jambi Antibiotic Resistence Test Against
Staphylococcus aureusCulture in Intensive Care Unit
(ICU) Hospital in Jambi. In Journal of Healthcare
Technology and Medicine (Vol. 6, Issue 1).
Sari, A., & Safitri, I. (2016). Studi Penggunaan Antibiotika
Pasien Pneumonia Anak di RS. PKUMuhammadiyah
Yogyakarta dengan Metode Defined Daily Dose (DDD).
Jurnal Ilmiah Ibnu Sina, 1(2), 151–162.
Sugihantoro, H., Hakim, A., Miya, N., Farmasi, Z. P.,
Kedokteran, F., & Kesehatan, I. (2020). Evaluasi kualitas
penggunaan antibiotika pada pasien pasca bedah dengan
metode gyssens di rsud bdh surabaya periode 2016. In
Jurnal Ilmu Farmasi dan Farmasi Klinik (JIFFK) (Vol.
, Issue 1).
www.unwahas.ac.id/publikasiilmiah/index.php/ilmu
farmasidanfarmasiklinik
Sukmawati, I. G. A. N. D., Adi Jaya, M. K., & Swastini,
D. A. (2020). Evaluasi Penggunaan Antibiotik pada Pasien
Tifoid Rawat Inap di Salah Satu Rumah Sakit Pemerintah
Provinsi Bali dengan Metode Gyssens dan ATC/DDD.
Jurnal Farmasi Udayana, 37.
https://doi.org/10.24843/jfu.2020.v09.i01.p06
van der Meer, J. W. M., & Gyssens, I. C. (2001). Quality
of antimicrobial drug prescription in hospital.
Clinical Microbiology and Infection, 7(SUPPL. 6),
–15. https://doi.org/10.1046/j.1469-0691.2001.00079.x
Virginia. (2019). Types of surgey.
http://repository.uinjkt.ac.id/dspace/bitstream/12345
/2324/1/NYI DEWI KURAESIN-FKIK.pdf
Wu, C. T., Chen, C. L., Lee, H. Y., Chang, C. J., Liu, P.
Y., Li, C. Y., Liu, M. Y., & Liu, C. H. (2017). Decreased
antimicrobial resistance and defined daily doses after
implementation of a clinical culture-guided antimicrobial
stewardship program in a local hospital. Journal of
Microbiology, Immunology and Infection, 50(6), 846–856.
https://doi.org/10.1016/j.jmii.2015.10.006
Yulia, R., Yuaraningtiyas, G., & Wiyono, H. (2017). Profil
Penggunaan Antibiotik dan Peta Kuman di Ruang Rawat
Inap Rs Husada Utama Surabaya.
Ikatan Apoteker Indonesia 2017, 12(1), 228–241.
Yurva, S., Lasabuda, S., & Gozali, D. (2021). Review
artikel: manfaat implementasi antimicrobial stewardship
program (asp) berdasarkan perhitungan define daily dose
(ddd) dalam penggunaan antibiotik. Farmaka, 19(3), 1–7.
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